The former France Under-18 midfielder and Congo international was a free agent, having been released by Oldham Athletic in the summer before Keith Curle's Hartlepool scooped up the midfielder earlier today.
Missilou, 30, is reuniting with Curle having previously played for the Pools manager at Northampton Town.
"Chris provides cover for the current injuries we've got but also comes in with great quality and experience," said Curle.
As well as the two aforementioned clubs, Missilou has also had short spells at both Swindon Town and Newport County.
He is set to make his debut in Hartlepool's League Two fixture away against Barrow.