Ipswich Town and Exeter City have not met in a league fixture in over 65 years, and to mark the occasion, an in-form Freddie Ladapo headed his ninth goal of the season to break the deadlock.
Despite only having a single shot on target throughout the 90', Exeter did respond well to falling behind as Alex Hartridge forced a sharp save from Christian Walton after the visitors struggled to clear their lines from a corner.
Grecians goalkeeper Jamal Blackman made two superb stops in a matter of minutes to deny Wes Burns and Ladapo.
Blackman couldn't maintain his heroics, however, as Marcus Harness glanced home the second midway through the second half to round off a routine victory in Devon.
The Tractor Boys stay in second despite putting pressure on Argyle, while Gary Caldwell's Grecians stay in ninth, four points outside the play-off positions.
Speaking to local radio after the match, Ipswich boss Kieran McKenna told the media,
""It was a solid, professional performance where we controlled the game in all aspects, really. It was a good bright start where we took the ball, dominated possession, created a couple of good chances and got the first goal.
"There were moments when we held our shape really well defensively and that was important, we'd worked on it and spoken about it during the week.
"There were lots of good things, it was important to get the two goals, the clean sheet and a good win." - Kieran McKenna
Alternately, Exeter boss Gary Caldwell told BBC Radio Devon,
"We said before the game they are very good - I'm pretty sure they'll get promoted. That was the best of what League One has to offer, but in terms of performance levels I think we were a bit off where we have been.
"The intensity of our press wasn't quite what it has been but I was delighted with the players' effort and application. They gave everything." - Gary Caldwell
"We have to learn the small lessons that we've been taught today. It's never good conceding goals but the second goal is from a set-piece and we've done a lot of work this week on defending set-pieces. It wasn't even a great delivery but we lose our man in the box. We were very much in the game at that point and thinking about changes to really go for it.
"Once it goes 2-0 it's a big ask from there."